Effective anticancer therapies destroy the tumor cells and have minimal effects on normal cells. Recent Chemoterapiile and X-ray treatment differ depending on the subtle differences of physiological proliferation and nutritional needs of normal and tumor cells. Unfortunately, drugs currently used are relatively nonspecifice, acting on a broad spectrum and kill or destroy a large number of normal cells with malignant cells. May we know that neoplasm of the same tissue are distinct from the genetic and physiological. This may explain for instance why a drug that has an effect on a particular type of limfom is not effective in treating another limfom.

An alternative way to develop effective chemotherapy appeared during the last 20 years of research that identified genetic lesions associated with various specific cancers. Therapies that are based on these genetic differences have proved more effective in targeting tumors without destroying normal cells. But recent surveys have shown that specific gene mutations are common for a wide variety of cancers. Some of the most preserved injuries occurring in the genes which play an important role in monitoring and maintaining genome integrity. For example, p53 gene mamaliana was estimated that mutations present in 50% of all human cancers.

Researchers from the laboratory of Dr Sullivan at the University of California, Santa Cruz, motivated by these data, have focused on the realization of tests in vivo for anticancer drugs. Chosen as a model to study Drosophila melanogaster due to the advantages which it presents. Like human beings, Drosophila is a complex of physiological point of view, showing several types of cells and tissues. Similar body, the body suffers musculitei fruit apoptosis, depending on the induction and development environment. Moreover, over 2 / 3 of the genes known to be involved in human diseases are conserved in Drosophila. Finally, this model can allow obtaining cytology analysis of high resolution in time, the effects of mutations on cell cycle inhibitors, a path that is not practical for human subjects. 

At Emory University, Atlanta, Dr. Victoria Finnerty is concerned with the research related to cancer. Colorectal cancer is affected by this second cause of death due to cancer in the United States. Cercetatoarea he studies focused on obtaining substantial progress in order elucidarii human colorectal cancer genetics. Research and its partners have highlighted the fact that the etiology of human colorectal cancer involves a series of mutations in genes responsible for regulating cell growth and differentiation. MCC gene, which has moved into human colorectal cancer, presumably it would play a key role in colorectal cancer genomics. Studies were conducted in cell culture systems in vitro, but have proven to be limited as a barrier to elucidating the role of MCC gene and other genes in colorectal cancers.

Starting from these limitations are imposed discovery system in vivo, which have technology for colorectal cancer study. Thus, Dr. Finnerty isolated from the fruit midge (Drosophila melanogaster), a homologous gene of human MCC, dMCC and individuals obtained mutants for gene of interest. DMCC gene from Drosophila coding for proteins that appear to have cellular functions similar to human proteins. Thus, information obtained by working with Drosophila model experimental and had to assign a possible role dMCC gene, a known metabolic pathway, or to discover a new metabolic pathway that leads to the development of experiments to test gene function in human Drosophila. During the performance experiments, Dr. Finnerty and collaborators have discovered midge fruit with tumors and appears corrupt. So these researchers have shown that Drosophila experimental model may lead to better understanding of gene function MCC, having allowed the investigation of a gene in a living organism, in vivo, is proving to be effective for colorectal cancer study, but and to identify other genes responsible for activation or suppression of tumor growth. Also, as an immediate consequence, researchers at Emory University have proposed the use of experimental purposes in Drosophila and the development of therapeutic strategies for colorectal cancers.

By using a simple model study, such as midge fruit can provide that can be accumulated knowledge base that can be useful and higher organisms, whereas approximately 80% of the molecules and mechanisms that are involved show a high degree of conservation between midge fruit and humans. Thus, Drosophila is an excellent model system for studying molecular mechanisms of tumorigenezei and contributes directly to understanding the biology of cancer. 
After declaring a war against cancer through the years’60, following recent discoveries in genetic research in humans and fruit midge, were identified a few specific genes, the so-called “cancer genes”, such as BRCA1, BRCA2, p53, Ras , ErbB and APC, which have contributed to the diagnosis and treatment of several cancers. Until these to be discovered genes, the only way of treatment consisted of surgery, radiation and chemotherapy. Later things changed, imunobiologia appeared as an area of cancer research. During the early 70’s were first developed antibodies multiclonali and thought is the best solution to a science so-called war against cancer. However, monoclonal antibodies have not hit targets in the first tests to combat cancer. Relatively recent scientific contributions in various fields, including genetics and musculitei fruit led to a better understanding of horses and signaling mechanisms targeting antibodies. Today, monoclonal antibodies are used for targeting effective components defective cancer cells. One of the monoclonal antibodies used in treating human cancer Herceptina. By binding to a receptor specifically blocks the signal Herceptina growth and abnormal cells shall cease to divide. Collaborative efforts between researchers in oncology, immunology and genetics of fruit musculitei resulted in a promising treatment that has restored the life of many affected persons, such contributions are exemplary and show the power of research in collaboration between specialists in scientific fields different.